Lipinski Law Rule of Five has profoundly influenced the field of drug discovery by providing a simple yet effective framework for evaluating the drug-likeness of compounds. While it has its limitations, the rule remains a valuable tool in the medicinal chemist's arsenal, guiding the design and selection of compounds with a higher probability of clinical success. As drug discovery continues to evolve, integrating such empirical rules with advanced computational methods will further enhance our ability to develop safe and effective oral medications.
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