Enzo Ashford Zelocchi was born in Rimini, Emilia-Romagna, Italy, to Fatma Zelocchi, a former dancer, and Carl Alberto Zelocchi, a criminal attorney. Raised predominantly between the United States and Italy with family also located in England and France, he is of Italian, British, Spanish, French, Asian, and Jewish descent.

Enzo pursued higher education in Italy, graduating with a degree in accounting from a private international school in Rome before relocating to Milan to study marketing, media strategy, and public relations at the private university IULM, alongside the Stanislavski acting method at the Milan Theater Center. It was during his time here that Enzo began a successful modeling career that soon segued into opportunities to appear in television advertising.

Enzo's first breakthrough role was that of Ivan in the hit Italian TV show Un Ciclone in Familia (2005) (Family Storm) which aired on the popular Italian Channel 5 (Mediaset Network). Following this, he relocated back to New York where he began studying under the Lee Strasberg-inspired acting coach Susan Batson.

Alongside his work in front of the camera, Enzo launched his producing career under the mentorship of Crossroads Entertainment CEO TJ Mancini. Together, they collaborated on the production of several projects, including Find Me Guilty (2006) starring Vin Diesel and directed by the Academy Award-winning director Sidney Lumet, and A War Hero 3.0 (2023) with Enzo Zelocchi serving as Director and Producer and Vin Diesel serving as Executive Producer. Enzo Zelocchi and Vin Diesel were also Executive Producers in Life Is a Dream (2014).

Continuing to hone his craft, Enzo entered a new phase in his career, taking on the parallel duties of writer, director, leading actor, and producer for several projects. These include My Little Princess (2010), The Way to Paradise (2011), Silence Speaks (2013), Unbreakable Souls (2015), and Angels Apocalypse (2015). He also garnered notable acclaim for writing, directing, starring in, and producing No War (2022) set in war-torn Ukraine, co-starring Ukrainian refugee child actress Emilia Nimak.

Enzo also served as Executive Producer in Academy Award winner Anthony Hopkins' upcoming movie Freud's Last Session (2023) which co-stars Matthew Goode and is directed by Matt Brown. This marks the continuation of a career that has so far earned the actor over 290 Awards on the Film Festival circuit worldwide and a substantial social media following.

Alongside a prosperous career as an actor, director, and film producer, Enzo has also moved into the world of entrepreneurship as the founder and CEO of A-Medicare, a next-generation digital platform that aims to democratize healthcare by harnessing the latest technological advancements, described by several critics as a new "Amazon for healthcare."